Sugita M, Jackman R M, van Donselaar E, Behar S M, Rogers R A, Peters P J, Brenner M B, Porcelli S A
Lymphocyte Biology Section, Division of Rheumatology and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Science. 1996 Jul 19;273(5273):349-52. doi: 10.1126/science.273.5273.349.
CD1 proteins have been implicated as antigen-presenting molecules for T cell-mediated immune responses, but their intracellular localization and trafficking remain uncharacterized. CD1b, a member of this family that presents microbial lipid antigens of exogenous origin, was found to localize to endocytic compartments that included the same specialized subset of endosomes in which major histocompatibility complex (MHC) class II molecules are proposed to bind endocytosed antigens. Unlike MHC class II molecules, which traffic to antigen-loading endosomal compartments [MHC class II compartments (MIICs)] primarily as a consequence of their association with the invariant chain, localization of CD1b to these compartments was dependent on a tyrosine-based motif in its own cytoplasmic tail.
CD1蛋白被认为是T细胞介导的免疫反应中的抗原呈递分子，但其细胞内定位和运输仍未明确。CD1b是该家族的一员，可呈递外源性微生物脂质抗原，它被发现定位于内吞区室，这些区室包括主要组织相容性复合体（MHC）II类分子被认为可结合内吞抗原的同一特殊内体亚群。与MHC II类分子不同，MHC II类分子主要由于与恒定链的结合而运输至抗原加载内体区室[MHC II类区室（MIIC）]，CD1b定位于这些区室取决于其自身胞质尾部的酪氨酸基序。
