鼠疫耶尔森菌血红素储存（hms）位点在跳蚤传播鼠疫中的作用。
Role of the Yersinia pestis hemin storage (hms) locus in the transmission of plague by fleas.
作者信息
Hinnebusch B J, Perry R D, Schwan T G
机构信息
Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
出版信息
Science. 1996 Jul 19;273(5273):367-70. doi: 10.1126/science.273.5273.367.
Yersinia pestis, the cause of bubonic plague, is transmitted by the bites of infected fleas. Biological transmission of plague depends on blockage of the foregut of the flea by a mass of plague bacilli. Blockage was found to be dependent on the hemin storage (hms) locus. Yersinia pestis hms mutants established long-term infection of the flea's midgut but failed to colonize the proventriculus, the site in the foregut where blockage normally develops. Thus, the hms locus markedly alters the course of Y. pestis infection in its insect vector, leading to a change in blood-feeding behavior and to efficient transmission of plague.
鼠疫耶尔森菌是腺鼠疫的病原体，通过受感染跳蚤的叮咬传播。鼠疫的生物传播取决于大量鼠疫杆菌堵塞跳蚤的前肠。研究发现堵塞取决于血红素储存（hms）基因座。鼠疫耶尔森菌hms突变体在跳蚤中肠建立了长期感染，但未能定殖在前胃，即前肠中通常发生堵塞的部位。因此，hms基因座显著改变了鼠疫耶尔森菌在其昆虫媒介中的感染进程，导致取食行为改变并实现鼠疫的有效传播。
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