鼠疫疫苗研发进展及行动呼吁

Progress on the research and development of plague vaccines with a call to action.

作者信息

Williamson E Diane, Kilgore Paul B, Hendrix Emily K, Neil Blake H, Sha Jian, Chopra Ashok K

机构信息

Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, UK.

Department of Microbiology and Immunology, UTMB, Galveston, TX, 77555, USA.

出版信息

NPJ Vaccines. 2024 Sep 7;9(1):162. doi: 10.1038/s41541-024-00958-1.

DOI:10.1038/s41541-024-00958-1

PMID:39242587

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11379892/

Abstract

There is a compelling demand for approved plague vaccines due to the endemicity of Yersinia pestis and its potential for pandemic spread. Whilst substantial progress has been made, we recommend that the global funding and health security systems should work urgently to translate some of the efficacious vaccines reviewed herein to expedite clinical development and to prevent future disastrous plague outbreaks, particularly caused by antimicrobial resistant Y. pestis strains.Content includes material subject to Crown Copyright © 2024.This is an open access article under the Open Government License ( http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/ ).

摘要

由于鼠疫耶尔森菌的地方性流行及其大流行传播的可能性，对已获批的鼠疫疫苗有迫切需求。尽管已取得重大进展，但我们建议全球资助和卫生安全系统应紧急行动，将本文所审查的一些有效疫苗转化应用，以加快临床开发，并预防未来灾难性的鼠疫暴发，尤其是由耐抗菌药物的鼠疫耶尔森菌菌株引起的暴发。内容包括受英国皇家版权© 2024保护的材料。这是一篇根据开放政府许可（http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/）发布的开放获取文章。