POU因子Oct-6与雪旺细胞分化

The POU factor Oct-6 and Schwann cell differentiation.

作者信息

Jaegle M, Mandemakers W, Broos L, Zwart R, Karis A, Visser P, Grosveld F, Meijer D

机构信息

Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University, Post Office Box 1738, 3000 DR Rotterdam, Netherlands.

出版信息

Science. 1996 Jul 26;273(5274):507-10. doi: 10.1126/science.273.5274.507.

DOI:10.1126/science.273.5274.507

PMID:8662541

Abstract

The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6(-/-) mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

摘要

POU转录因子Oct-6，也被称为SCIP或Tst-1，被认为是雪旺细胞分化过程中的主要转录调节因子。对出生后不同发育阶段的Oct-6基因敲除小鼠坐骨神经进行显微镜和免疫化学分析发现，雪旺细胞分化延迟，在髓鞘形成前期出现短暂停滞。因此，Oct-6似乎是前髓鞘细胞向髓鞘形成细胞转变所必需的。一旦这些细胞越过这一阶段，就不再需要Oct-6，髓鞘形成也会正常发生。