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本文引用的文献

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The relationship between axons and Schwann cells during development of peripheral nerves in the rat.大鼠外周神经发育过程中轴突与施万细胞之间的关系。
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Differential regulation of the zinc finger genes Krox-20 and Krox-24 (Egr-1) suggests antagonistic roles in Schwann cells.锌指基因Krox-20和Krox-24（Egr-1）的差异调节表明它们在雪旺细胞中具有拮抗作用。
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The biology and pathobiology of Schwann cells.施万细胞的生物学与病理生物学
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P0 is constitutively expressed in the rat neural crest and embryonic nerves and is negatively and positively regulated by axons to generate non-myelin-forming and myelin-forming Schwann cells, respectively.P0在大鼠神经嵴和胚胎神经中组成性表达，并分别受到轴突的负调控和正调控，以产生非髓鞘形成的施万细胞和髓鞘形成的施万细胞。
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Molecular genetics of demyelination: new wrinkles on an old membrane.脱髓鞘的分子遗传学：古老细胞膜上的新褶皱
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The Transcription Factors SCIP and Krox-20 Mark Distinct Stages and Cell Fates in Schwann Cell Differentiation.转录因子SCIP和Krox-20在雪旺细胞分化中标记不同阶段和细胞命运。
Mol Cell Neurosci. 1996 Aug;8(2/3):129-45. doi: 10.1006/mcne.1996.0052.
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Embryonic Development of Schwann Cells: Multiple Roles for Neuregulins along the Pathway.施万细胞的胚胎发育：神经调节蛋白在该过程中的多重作用
Mol Cell Neurosci. 1996 Aug;8(2/3):71-5. doi: 10.1006/mcne.1996.0045.
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Oct-6 (SCIP/Tst-1) is expressed in Schwann cell precursors, embryonic Schwann cells, and postnatal myelinating Schwann cells: comparison with Oct-1, Krox-20, and Pax-3.Oct-6（SCIP/Tst-1）在雪旺细胞前体、胚胎期雪旺细胞和出生后形成髓鞘的雪旺细胞中表达：与Oct-1、Krox-20和Pax-3的比较。
J Neurosci Res. 1996 Dec 1;46(5):630-40. doi: 10.1002/(SICI)1097-4547(19961201)46:5<630::AID-JNR11>3.0.CO;2-0.
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Schwann cell differentiation.施万细胞分化
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The zinc finger transcription factor Zif268/Egr-1 is essential for Schwann cell expression of the p75 NGF receptor.锌指转录因子Zif268/Egr-1对于雪旺细胞中p75神经生长因子受体的表达至关重要。
Mol Cell Neurosci. 1995 Aug;6(4):337-48. doi: 10.1006/mcne.1995.1026.

成髓鞘施万细胞表达Tst-1/SCIP/Oct-6。

Promyelinating Schwann cells express Tst-1/SCIP/Oct-6.

作者信息

Arroyo E J, Bermingham J R, Rosenfeld M G, Scherer S S

机构信息

Department of Neuroscience, The University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6077, USA.

出版信息

J Neurosci. 1998 Oct 1;18(19):7891-902. doi: 10.1523/JNEUROSCI.18-19-07891.1998.

DOI:10.1523/JNEUROSCI.18-19-07891.1998
PMID:9742157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6792991/
Abstract

Tst-1/SCIP/Oct-6, a POU domain transcription factor, is transiently expressed by developing Schwann cells and is required for their normal development into a myelinating phenotype. In tst-1/scip/oct-6-null sciatic nerves, Schwann cells are transiently arrested at the "promyelinating" stage, when they have a one-to-one relationship with an axon but before they have elaborated a myelin sheath. To determine when Schwann cells express Tst-1/SCIP/Oct-6, we examined beta-galactosidase (beta-gal) expression in heterozygous tst-1/scip/oct-6 mice, in which one copy of the tst-1/scip/oct-6 gene has been replaced with the LacZ gene. beta-Gal expression from the LacZ gene seems to parallel Tst-1/SCIP/Oct-6 expression from the endogenous tst-1/scip/oct-6 gene in developing and regenerating sciatic nerves. Furthermore, electron microscopic examination of 5bromo-4-chloro-3-indolyl-beta-D-galactopyranoside- (X-gal) and halogenated indolyl-beta-D-galactoside- (Bluo-gal) stained nerves showed that promyelinating Schwann cells express the highest levels of beta-gal, both in developing and in regenerating nerves. Thus, the expression of beta-gal, a surrogate marker of Tst-1/SCIP/Oct-6, peaks at the same stage of Schwann cell development at which development is arrested in tst-1/scip/oct-6-null mice, indicating that Tst-1/SCIP/Oct-6 has a critical role in promyelinating Schwann cells.

摘要

Tst-1/SCIP/Oct-6是一种POU结构域转录因子，由发育中的雪旺细胞短暂表达，是其正常发育为有髓鞘表型所必需的。在tst-1/scip/oct-6基因缺失的坐骨神经中，雪旺细胞在“前髓鞘形成”阶段短暂停滞，此时它们与轴突呈一对一关系，但尚未形成髓鞘。为了确定雪旺细胞何时表达Tst-1/SCIP/Oct-6，我们检测了杂合子tst-1/scip/oct-6小鼠中β-半乳糖苷酶（β-gal）的表达，其中一个tst-1/scip/oct-6基因拷贝已被LacZ基因取代。在发育和再生的坐骨神经中，LacZ基因的β-gal表达似乎与内源性tst-1/scip/oct-6基因的Tst-1/SCIP/Oct-6表达平行。此外，对5-溴-4-氯-3-吲哚基-β-D-吡喃半乳糖苷（X-gal）和卤代吲哚基-β-D-半乳糖苷（Bluo-gal）染色的神经进行电子显微镜检查发现，无论是在发育中的还是再生的神经中，前髓鞘形成的雪旺细胞表达的β-gal水平最高。因此，作为Tst-1/SCIP/Oct-6替代标志物的β-gal的表达，在雪旺细胞发育的同一阶段达到峰值，而在tst-1/scip/oct-6基因缺失的小鼠中，雪旺细胞发育在该阶段停滞，这表明Tst-1/SCIP/Oct-6在前髓鞘形成的雪旺细胞中起关键作用。