局部应用盐酸阿可乐定对视神经的血管运动效应。

Optic nerve vasomotor effects of topical apraclonidine hydrochloride.

作者信息

Orgül S, Bacon D R, Van Buskirk E M, Cioffi G A

机构信息

Devers Eye Institute, Legacy Portland Hospitals, Oregon, USA.

出版信息

Br J Ophthalmol. 1996 Jan;80(1):82-4. doi: 10.1136/bjo.80.1.82.

DOI:10.1136/bjo.80.1.82

PMID:8664240

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC505390/

Abstract

AIMS

To examine, in vivo, the anterior optic nerve vasomotor effects of chronic apraclonidine hydrochloride in rabbits.

METHODS

After local treatment in one randomly chosen eye with apraclonidine hydrochloride 0.5% over 21 days, the microvasculature of the optic nerve was examined in five rabbits using an intraluminal microvascular corrosion casting technique. The investigators were masked as to which eye was treated. The vasoconstriction near the branching point of arterioles supplying the optic nerve was calculated as a percentage of the downstream vessel calibre. An average constriction was calculated and compared between the treated and the contralateral, untreated, eyes by means of a two tailed t test for paired variables. Constriction values of a total of 72 arterioles supplying the optic nerve were obtained for the five rabbits.

RESULTS

The average constriction in the treated and the control eyes was comparable (p = 0.96).

CONCLUSION

Chronic administration of apraclonidine hydrochloride 0.5% produces no observable optic nerve vasomotor effects in the rabbit eye.

摘要

目的

在兔体内研究长期使用盐酸阿可乐定对眼神经前支血管舒缩功能的影响。

方法

随机选择一只眼睛，用0.5%盐酸阿可乐定局部治疗21天，然后用管腔内微血管铸型技术检查5只兔子的视神经微血管系统。研究人员对哪只眼睛接受了治疗并不知情。供应视神经的小动脉分支点附近的血管收缩程度以其下游血管管径的百分比来计算。计算平均收缩程度，并通过配对变量的双尾t检验比较治疗眼和对侧未治疗眼之间的差异。从5只兔子身上共获得了72条供应视神经的小动脉的收缩值。