绝经后乳腺癌病因中的血清类固醇激素水平、性激素结合球蛋白和体重指数。

Serum steroid hormone levels, sex hormone-binding globulin, and body mass index in the etiology of postmenopausal breast cancer.

作者信息

Lipworth L, Adami H O, Trichopoulos D, Carlström K, Mantzoros C

机构信息

Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.

出版信息

Epidemiology. 1996 Jan;7(1):96-100. doi: 10.1097/00001648-199601000-00017.

DOI:10.1097/00001648-199601000-00017

PMID:8664410

Abstract

Serum concentrations of estrone, androstenedione, testosterone, and sex hormone-binding globulin (SHBG) were measured postoperatively in 122 postmenopausal women with incident breast cancer and 122 age-matched population controls. After mutual adjustment, through conditional logistic regression, between the hormonal variables and body mass index (BMI), the odds ratios for increasing control-defined quartiles of estrone and androstenedione, respectively, were 1.00, 1.44, 1.76, 1.94 and 1.00, 0.83, 0.97, 2.43; there was no association of testosterone with breast cancer risk. Moreover, the odds ratios for increasing quartiles of SHBG and BMI were 1.00, 0.72, 0.28, 0.25 and 1.00, 0.39, 0.28, 0.19, respectively. This study reveals sharp contrasts in breast cancer risk between women with high estrone and low BMI and SHBG, vs women with low estrone and high BMI and SHBG.

摘要

对122例新发乳腺癌的绝经后女性及122例年龄匹配的人群对照者术后测定了血清雌酮、雄烯二酮、睾酮及性激素结合球蛋白（SHBG）浓度。在对激素变量和体重指数（BMI）进行相互调整后，通过条件逻辑回归分析，雌酮和雄烯二酮按对照定义的四分位数增加时的优势比分别为1.00、1.44、1.76、1.94和1.00、0.83、0.97、2.43；睾酮与乳腺癌风险无关联。此外，SHBG和BMI按四分位数增加时的优势比分别为1.00、0.72、0.28、0.25和1.00、0.39、0.28、0.19。本研究揭示了雌酮水平高且BMI和SHBG水平低的女性与雌酮水平低且BMI和SHBG水平高的女性在乳腺癌风险上的鲜明对比。