Kahmann R, Romeis T, Bölker M, Kämper J
Ludwig-Maximilians-Universität München, Germany.
Curr Opin Genet Dev. 1995 Oct;5(5):559-64. doi: 10.1016/0959-437x(95)80023-9.
In the fungus Ustilago maydis, the ability to distinguish between partners that are of the same or of different mating type is controlled by two mating-type loci. One locus allows extracellular recognition though a pheromone-based system. After cell fusion, the other mating-type locus, which exists in multiple alleles, determines intracellular recognition. Each allele encodes a pair of homeodomain proteins that are active only in pairwise combinations in which the two partners originate from different alleles of the locus. Recent discoveries suggest that the underlying molecular recognition mechanism is the ability to form heterodimers. Whereas the proteins in all different allelic combinations interact, it is a specific feature of proteins from the same allele not to interact. This suggests the existence of a code for protein-protein recognition.
在真菌玉米黑粉菌中，区分相同或不同交配型伴侣的能力由两个交配型基因座控制。一个基因座通过基于信息素的系统实现细胞外识别。细胞融合后，另一个存在多个等位基因的交配型基因座决定细胞内识别。每个等位基因编码一对同源域蛋白，这些蛋白仅在两个伴侣来自该基因座不同等位基因的成对组合中才具有活性。最近的发现表明，潜在的分子识别机制是形成异二聚体的能力。虽然所有不同等位基因组合中的蛋白质都会相互作用，但来自同一等位基因的蛋白质不相互作用是一个特定特征。这表明存在蛋白质 - 蛋白质识别密码。
