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全科医疗中神经症患者的长期预后。

Long-term outcome of patients with neurotic illness in general practice.

作者信息

Lloyd K R, Jenkins R, Mann A

机构信息

Mental Health Research Unit, University of Exeter.

出版信息

BMJ. 1996 Jul 6;313(7048):26-8. doi: 10.1136/bmj.313.7048.26.

Abstract

OBJECTIVE

To determine the 11 year outcome of neurotic disorder in general practice.

DESIGN

Cohort study over 11 years.

SETTING

Two general practices in Warwickshire England.

SUBJECTS

100 patients selected to be representative of those identified nationally by general practitioners as having neurotic disorders.

MAIN OUTCOME MEASURES

Mortality, morbidity, and use of health services.

RESULTS

At 11 years 87 subjects were traced. The 11 year standardised mortality ratio was 173 (95% confidence interval 164 to 200). 47 were cases on the general health questionnaire, 32 had a relapsing or chronic psychiatric course, and 49 a relapsing or chronic physical course. Treatment for psychiatric illness was mainly drugs. The mean number of consultations per year was 10.8 (median 8.7). A persistent psychiatric diagnosis at one year follow up was associated with high attendance ( > 12 visits a year for 11 years) at follow up after age, sex, and physical illness were adjusted for. Severity of psychiatric illness (general health questionnaire score) at outset predicted general health questionnaire score at 11 year follow up, course of psychiatric illness, and high consultation rate.

CONCLUSION

These data support the view that a neurotic illness can become chronic and is associated with raised mortality from all causes and high use of services. Such patients need effective intervention, particularly those with a more severe illness who do not recover within one year.

摘要

目的

确定全科医疗中神经症性障碍的11年转归情况。

设计

11年队列研究。

地点

英国沃里克郡的两家全科医疗诊所。

研究对象

选取100例患者,这些患者被选为全科医生在全国范围内识别出的患有神经症性障碍患者的代表。

主要观察指标

死亡率、发病率及卫生服务利用情况。

结果

11年后追踪到87例患者。11年标准化死亡率为173(95%置信区间为164至200)。在一般健康问卷上,47例为病例,32例有复发或慢性精神科病程,49例有复发或慢性躯体病程。精神疾病的治疗主要是药物治疗。每年的平均就诊次数为10.8次(中位数为8.7次)。在调整年龄、性别和躯体疾病因素后,1年随访时持续的精神科诊断与随访期间的高就诊率(11年中每年就诊>12次)相关。疾病开始时的精神疾病严重程度(一般健康问卷评分)可预测11年随访时的一般健康问卷评分、精神疾病病程及高就诊率。

结论

这些数据支持以下观点,即神经症性疾病可发展为慢性,且与全因死亡率升高及高服务利用率相关。此类患者需要有效的干预措施,尤其是那些病情较重且1年内未康复的患者。

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