Hsu W H, Ikezoe J, Chen C Y, Kwan P C, Hsu C P, Hsu N Y, Chiang C D, HO W L
Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 1):1938-51. doi: 10.1164/ajrccm.153.6.8665059.
Sixty-eight patients with thoracic lesions (48 with lung cancer and 20 with benign lesions) underwent color Doppler ultrasound (US) examinations. Of those, 21 patients (13 with lung cancer and eight with benign lesions) also received resections, and the correlation between color Doppler US signals and resected histologic specimens was evaluated. Our results showed that three patterns of color Doppler US signals could be detected and confirmed: pulsatile flow (artery), constant flow, and triphasic flow (pulmonary vein). Among the 48 patients with lung cancer, pulsatile flow, constant flow, and/or triphasic flow were detected in 34 (71%), 24 (50%), and 14 (29%), respectively. Among the 20 patients with benign lesions, only pulsatile flow and/or triphasic flow were detected in nine (45%) and eight (40%), respectively. From the correlation between color Doppler US signals and histologic specimens, constant flow was representative of the true neovascularity of lung cancers, and it was valuable for differentiating lung cancers from benign lesions (p = 0.00008, sensitivity = 0.50, and specificity = 1.0). Although color Doppler US still had some limitations in detecting blood vessels in thoracic lesions, the correlation between the vascularity represented by color Doppler US signals and histologic specimens was excellent. We conclude that color Doppler US is a valuable method for assessing blood flow in thoracic lesions and differentiating lung cancers from intrapulmonary benign lesions.
68例胸部病变患者（48例肺癌患者和20例良性病变患者）接受了彩色多普勒超声（US）检查。其中，21例患者（13例肺癌患者和8例良性病变患者）也接受了手术切除，并评估了彩色多普勒超声信号与切除的组织学标本之间的相关性。我们的结果显示，可以检测并确认三种彩色多普勒超声信号模式：搏动性血流（动脉）、持续性血流和三相血流（肺静脉）。在48例肺癌患者中，分别有34例（71%）、24例（50%）和14例（29%）检测到搏动性血流、持续性血流和/或三相血流。在20例良性病变患者中，分别有9例（45%）和8例（40%）检测到仅搏动性血流和/或三相血流。从彩色多普勒超声信号与组织学标本之间的相关性来看，持续性血流代表肺癌真正的新生血管，对于鉴别肺癌与良性病变有价值（p = 0.00008，敏感性 = 0.50，特异性 = 1.0）。尽管彩色多普勒超声在检测胸部病变血管方面仍有一些局限性，但彩色多普勒超声信号所代表的血管分布与组织学标本之间的相关性良好。我们得出结论，彩色多普勒超声是评估胸部病变血流以及鉴别肺癌与肺内良性病变的一种有价值的方法。
