[医学和护理专业学生甲型肝炎病毒感染的血清流行病学。疫苗接种的作用]
[Seroepidemiology of hepatitis A virus infection in medical and nursing students. The role of vaccination].
作者信息
Buti M, Campins M, Jardí R, Navas E, Cotrina M, Llobet E, Vaqué J, Esteban R
机构信息
Servicio de Hepatología, Ciutat Sanitaria Vall d'Hebron, Universidad Autónoma de Barcelona.
出版信息
Gastroenterol Hepatol. 1996 Apr;19(4):199-202.
BACKGROUND
Recent seroepidemiologic studies have demonstrated a decrease in the prevalence of hepatitis A virus infection (HAV) in relation with an improvement in hygienic conditions. The prevalence of anti-HAV in a group of health care students was studied and a vaccination program initiated in this collective.
METHODS
Serum anti-HAV determination was performed by an enzymoimmunoanalysis method. A inactivated hepatitis A vaccine was administered.
RESULTS
Only 18.5% of the subjects between 17-23 years-old presented anti-HAV antibodies. The prevalence of anti-HAV was related with age and the number of partners. All of the 129 immunized individuals responded to the HAV vaccine with protector antibody titles.
CONCLUSION
The present study demonstrates the decrease in HAV infection among youths as well as the immunogenicity of the anti-hepatitis A vaccine.
背景
近期血清流行病学研究表明，随着卫生条件的改善，甲型肝炎病毒感染（HAV）的患病率有所下降。对一组医护专业学生的抗-HAV患病率进行了研究，并在这个群体中启动了疫苗接种计划。
方法
采用酶免疫分析法进行血清抗-HAV检测。接种一剂甲型肝炎灭活疫苗。
结果
17至23岁的受试者中只有18.5%呈现抗-HAV抗体。抗-HAV的患病率与年龄及性伴侣数量有关。129名接种疫苗者均产生了具有保护作用的抗体水平。
结论
本研究证明了青少年中HAV感染率的下降以及甲型肝炎疫苗的免疫原性。
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