Purcell H, Mulcahy D
Royal Brompton Hospital, London, UK.
J Cardiovasc Risk. 1995 Dec;2(6):510-4.
There is much current interest in the development of therapeutic strategies which may alter the circadian pattern of cardiovascular events such as myocardial infarction and sudden cardiac death. It is not known whether manipulating rhythmic processes and providing active medication at the most vulnerable periods during the day or night will protect patients and reduce the risk of death. This review examines the evidence from the limited available data and assess the feasibility of implementing such strategies.
目前人们对开发治疗策略非常感兴趣，这些策略可能会改变心血管事件（如心肌梗死和心源性猝死）的昼夜模式。尚不清楚在白天或晚上最脆弱的时间段操纵节律过程并提供活性药物是否会保护患者并降低死亡风险。本综述研究了有限可用数据中的证据，并评估了实施此类策略的可行性。
