Tsutsumi T, Hirano M, Matsumoto T, Nakamura K, Hashimoto K, Hondo H, Yonezawa Y, Tsukashima A, Nakane H, Uchimura H
Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, Saga, Japan.
Clin Neuropharmacol. 1995 Feb;18(1):64-71. doi: 10.1097/00002826-199502000-00008.
The effects of dopamine receptor antagonists on phencyclidine (PCP)-induced behaviors were examined in rats. Acute administration with PCP (7.5 mg/kg i.p.) produced various behavioral changes, such as increases of spontaneous activity, head-weaving, sniffing, rearing, back-pedaling, and ataxia. To determine which dopamine receptor subtypes were involved in mediating the PCP-induced behaviors, SCH 23390 (0.05 and 0.5 mg/kg), sulpiride (20 and 100 mg/kg), or haloperidol (0.05 and 0.5 mg/kg) were pretreated 30 min before PCP treatment (7.5 mg/kg). A higher dose of SCH 23390 significantly reduced the increase of spontaneous activity induced by PCP. Both doses of sulpiride did not affect the PCP-induced behaviors. A higher dose of haloperidol decreased the PCP-induced spontaneous activity, whereas a lower dose of haloperidol enhanced the activity. Ketanserin (0.5 and 5 mg/kg) did not alter any PCP-induced behaviors. These results suggest that the D1, but not D2, dopamine receptor subtype may be involved in the PCP-induced behavioral abnormality.
在大鼠中研究了多巴胺受体拮抗剂对苯环己哌啶（PCP）诱导行为的影响。急性给予PCP（7.5mg/kg腹腔注射）会产生各种行为变化，如自发活动增加、头部摆动、嗅探、竖毛、后退和共济失调。为了确定哪些多巴胺受体亚型参与介导PCP诱导的行为，在PCP治疗（7.5mg/kg）前30分钟预处理SCH 23390（0.05和0.5mg/kg）、舒必利（20和100mg/kg）或氟哌啶醇（0.05和0.5mg/kg）。较高剂量的SCH 23390显著降低了PCP诱导的自发活动增加。两种剂量的舒必利均未影响PCP诱导的行为。较高剂量的氟哌啶醇降低了PCP诱导的自发活动，而较低剂量的氟哌啶醇增强了活动。酮色林（0.5和5mg/kg）未改变任何PCP诱导的行为。这些结果表明，D1而非D2多巴胺受体亚型可能参与了PCP诱导的行为异常。
