Popoli P, Caporali M G, Scotti de Carolis A
Laboratorio di Farmacologia, Instituto Superiore di Sanità, Roma, Italy.
Pharmacol Res. 1990 Mar-Apr;22(2):197-205. doi: 10.1016/1043-6618(90)90716-q.
A behavioural study on the effects of D1 and D2 dopamine receptor antagonists (SCH 23390 and sulpiride respectively) and of an A1 adenosine receptor agonist (N6-L-phenylisopropyladenosine, L-PIA) against phencyclidine (PCP)-induced effects was assessed in adult male rabbits. SCH 23390 (0.003-0.01 mg/kg i.v.) and sulpiride (12.5 mg/kg i.v.) were able to significantly prevent PCP-induced stereotypy. Ataxia was reduced by SCH 23390 (0.003 mg/kg i.v.), while it was potentiated by sulpiride (12.5 mg/kg i.v.). Given alone at 12.5 mg/kg, sulpiride induced some EEG and behavioural effects in rabbits, while SCH 23390 (0.003 and 0.01 mg/kg) did not. L-PIA prevented both PCP-induced stereotypy and ataxia at the dose (0.1 mg/kg i.v.) devoid of behavioural or EEG effects by itself. Our results suggest that D1 dopamine receptors might play a more important role than D2 receptors in the expression of PCP-induced behaviour. They also propose that A1 adenosine receptors might be involved (e.g. via an influence on the dopamine release) in the behavioural effects of PCP.
在成年雄性兔中评估了D1和D2多巴胺受体拮抗剂（分别为SCH 23390和舒必利）以及A1腺苷受体激动剂（N6-L-苯基异丙基腺苷，L-PIA）对苯环己哌啶（PCP）诱导效应的行为学研究。SCH 23390（0.003 - 0.01毫克/千克静脉注射）和舒必利（12.5毫克/千克静脉注射）能够显著预防PCP诱导的刻板行为。SCH 23390（0.003毫克/千克静脉注射）可减轻共济失调，而舒必利（12.5毫克/千克静脉注射）则增强共济失调。单独给予12.5毫克/千克的舒必利会在兔中诱导一些脑电图和行为效应，而SCH 23390（0.003和0.01毫克/千克）则不会。L-PIA在自身无行为或脑电图效应的剂量（0.1毫克/千克静脉注射）下可预防PCP诱导的刻板行为和共济失调。我们的结果表明，D1多巴胺受体在PCP诱导行为的表达中可能比D2受体发挥更重要的作用。它们还提出，A1腺苷受体可能（例如通过对多巴胺释放的影响）参与PCP的行为效应。
