脯氨酰-亮氨酰-甘氨酰胺、促甲状腺激素释放激素和β-内啡肽-（10-16），与抗抑郁药一样，可拮抗褪黑素诱导的大鼠行为变化。

Prolyl-leucyl-glycinamide, thyrotropin-releasing hormone and beta-endorphin-(10-16), like antidepressants, antagonize melatonin-induced behavioural changes in rats.

作者信息

Hatta K, Wolterink G, Van Ree J M

机构信息

Rudolf Magnus Institute for Neurosciences, Medical Faculty, University of Utrecht, The Netherlands.

出版信息

Eur J Pharmacol. 1995 Sep 25;284(3):327-30. doi: 10.1016/0014-2999(95)00473-x.

DOI:10.1016/0014-2999(95)00473-x

PMID:8666016

Abstract

beta-Endorphin-(10-16), as well as a variety of antidepressants, has been reported to block the behavioural changes induced by injecting melatonin into the nucleus accumbens. In the present study the influence of subcutaneously administered prolyl-leucyl-glycinamide (PLG) and thyrotropin-releasing hormone (TRH) on the behavioural changes induced by melatonin administration in the nucleus accumbens were investigated and compared with that of beta-endorphin-(10-16). PLG and TRH were found to be as effective as beta-endorphin-(10-16) in counteracting the melatonin-induced behavioural changes. The data suggest that these peptides may serve as a starting point for the development of a new class of antidepressants.

摘要

据报道，β-内啡肽-（10-16）以及多种抗抑郁药可阻断向伏隔核注射褪黑素所诱导的行为变化。在本研究中，研究了皮下注射脯氨酰-亮氨酰-甘氨酰胺（PLG）和促甲状腺激素释放激素（TRH）对向伏隔核注射褪黑素所诱导的行为变化的影响，并与β-内啡肽-（10-16）的影响进行了比较。发现PLG和TRH在抵消褪黑素诱导的行为变化方面与β-内啡肽-（10-16）同样有效。数据表明，这些肽可能作为开发新型抗抑郁药的起点。