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Antagonism of morphine-induced catalepsy by L-prolyl-L-leucyl-glycinamide.

作者信息

Chiu S, Mishra R K

出版信息

Eur J Pharmacol. 1979 Jan 1;53(2):119-25. doi: 10.1016/0014-2999(79)90156-0.

DOI:10.1016/0014-2999(79)90156-0
PMID:32058
Abstract

In view of the recently demonstrated extra-endocrine central actions of hypothalamic releasing hormones, we have investigated the effects of prolyl-leucyl-glycinamide (PLG) and thyrotropin releasing hormone (TRH) on morphine-induced catalepsy. Although acute administration of PLG (10 mg kg-1 s.c.) slightly attenuated the cataleptic response, chronic PLG treatment (10 mg kg-1 s.c. for 10 days) virtually abolished morphine-induced catalepsy. TRH, administered subcutaneously, exhibited little or no anti-cataleptic activity. These results are discussed in relation to the possible central site of narcotic-induced catalepsy and the therapeutic potential of PLG in Parkinson's disease.

摘要

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引用本文的文献

1
Effects of dopaminergic and cholinergic drugs. naloxone and l-prolyl-leucyl-glycinamide on LSD-induced catalepsy.多巴胺能和胆碱能药物、纳洛酮及L-脯氨酰-亮氨酰-甘氨酰胺对麦角酰二乙胺所致僵住症的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Aug;313(1):45-50. doi: 10.1007/BF00505804.