Vajtai I, Varga Z, Aguzzi A
Institute of Neuropathology, University Hospital, Zürich, Switzerland.
Pathol Res Pract. 1997;193(9):617-21. doi: 10.1016/S0344-0338(97)80039-8.
We describe a composite glio-neuronal tumor comprising pleomorphic xanthoastrocytoma (PXA) and ganglioglioma identified in a left temporal biopsy. The 32-year-old male patient underwent surgery following a clinical history of persistent headaches of 6 years' duration. Immunohistochemical double labeling with antibodies to synaptophysin, beta-tubulin isotype III, GFAP and CD44H demonstrated neoplastic neurons and astrocytes in the ganglioglioma, while coexpression of glial and neuronal markers was found in a subset of PXA tumor cells variously showing giant cell or spindle cell morphology. There were gradual transitions between the two neoplastic populations. These findings raise the possibility of ganglioglioma having evolved by differentiation of bipotential PXA tumor cells along astrocytic and neuronal lineages. The PXA may, therefore, be closely related to desmoplastic neuroepithelial tumors of infancy, a group of neoplasms of presumed embryonal origin.
我们描述了在左侧颞叶活检中发现的一种由多形性黄色星形细胞瘤（PXA）和神经节胶质瘤组成的复合性胶质神经元肿瘤。该32岁男性患者因持续6年的头痛病史接受了手术。用抗突触素、β-微管蛋白Ⅲ型、GFAP和CD44H抗体进行免疫组织化学双重标记显示，神经节胶质瘤中有肿瘤性神经元和星形胶质细胞，而在不同表现为巨细胞或梭形细胞形态的PXA肿瘤细胞亚群中发现了胶质和神经元标志物的共表达。两个肿瘤群体之间存在逐渐过渡。这些发现增加了神经节胶质瘤可能由双潜能PXA肿瘤细胞沿星形细胞和神经元谱系分化演变而来的可能性。因此，PXA可能与婴儿促纤维增生性神经上皮肿瘤密切相关，这是一组推测起源于胚胎的肿瘤。
