Pham-Dinh D, Della Gaspera B, Kerlero de Rosbo N, Dautigny A
Unité 1488 du Centre National de la Recherche Scientifique, Laboratoire de Neurogénétique Moléculaire, Université de Paris VI, France.
Genomics. 1995 Sep 20;29(2):345-52. doi: 10.1006/geno.1995.9995.
Myelin/oligodendrocyte glycoprotein (MOG), a specific component of the central nervous system localized on the outermost lamellae of mature myelin, is a member of the immunoglobulin superfamily. We report here the organization of the human MOG gene, which spans approximately 17 kb, and the characterization of six MOG mRNA splicing variants. The intron/exon structure of the human MOG gene confirmed the splicing pattern, supporting the hypothesis that mRNA isoforms could arise by alternative splicing of a single gene. In addition to the eight exons coding for the major. MOG isoform, the human MOG gene also contains, in the 3' region, a previously unknown alternatively spliced coding exon, VIA. Alternative utilization of two acceptor splicing sites for exon VIII could produce two different C-termini. The nucleotide sequences presented here may be a useful tool to study further possible involvement of the MOG gene in hereditary neurological disorders.
髓鞘/少突胶质细胞糖蛋白（MOG）是中枢神经系统的一种特定成分，定位于成熟髓鞘的最外层薄片，属于免疫球蛋白超家族。我们在此报告人类MOG基因的结构，该基因跨度约17 kb，以及六种MOG mRNA剪接变体的特征。人类MOG基因的内含子/外显子结构证实了剪接模式，支持了mRNA异构体可能由单个基因的可变剪接产生的假说。除了编码主要MOG异构体的八个外显子外，人类MOG基因在3'区域还包含一个先前未知的可变剪接编码外显子VIA。外显子VIII的两个受体剪接位点的交替使用可产生两个不同的C末端。本文提供的核苷酸序列可能是进一步研究MOG基因在遗传性神经疾病中可能作用的有用工具。
