Burden R P, Dathan J R, Etherington M D, Guyer P B, MacIver A G
Lancet. 1979 Apr 28;1(8122):897-900. doi: 10.1016/s0140-6736(79)91374-6.
Nine patients with the loin-pain/haematuria syndrome are described. The previously reported clinical features of severe recurrent loin pain and tenderness in young women, the relationship of symptoms to use of oral contraceptives, and the demonstration of intrarenal vascular abnormalities by angiography are confirmed. Histology revealed minor non-specific abnormalities, and electron microscopy showed fibrin in the afferent arteriole and in glomerular capillaries of one patient only. No diagnostic changes were found on renography. In all patients except one the heparin-thrombin clotting-time was abnormal, suggesting increased platelet activity or release and providing further evidence of a vascular disorder.
本文描述了9例腰痛/血尿综合征患者。先前报道的年轻女性严重复发性腰痛和压痛的临床特征、症状与口服避孕药使用的关系以及血管造影显示的肾内血管异常均得到证实。组织学显示轻微的非特异性异常，电子显微镜检查仅在1例患者的入球小动脉和肾小球毛细血管中发现纤维蛋白。肾造影未发现诊断性改变。除1例患者外，所有患者的肝素-凝血酶凝血时间均异常，提示血小板活性增加或释放，为血管疾病提供了进一步证据。
