Wang L F, Lin J Y, Hsieh K H, Lin R H
Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China.
J Immunol. 1996 Jun 1;156(11):4077-82.
Hapten-induced contact hypersensitivity has been well-characterized in humans as well as in animal models. However, it is not clear whether or not protein Ag can directly sensitize epicutaneously and induce a primary immune response. We demonstrated in this study, for the first time, that through epicutaneous exposure protein Ag in the absence of adjuvant sensitizes animals and induces a predominant Th2-like response. Furthermore, mice receiving repeated protein Ag sustained elevated levels of specific IgE. This animal model can be used to investigate the molecular mechanism controlling the differential Th1/Th2 development in skin diseases.
半抗原诱导的接触性超敏反应在人类以及动物模型中已得到充分表征。然而，尚不清楚蛋白质抗原是否能直接经皮致敏并诱导初次免疫反应。我们在本研究中首次证明，在无佐剂的情况下经皮暴露蛋白质抗原可使动物致敏并诱导主要的Th2样反应。此外，反复接受蛋白质抗原的小鼠特异性IgE水平持续升高。该动物模型可用于研究控制皮肤疾病中Th1/Th2分化的分子机制。
