Kündig T M, Bachmann M F, DiPaolo C, Simard J J, Battegay M, Lother H, Gessner A, Kühlcke K, Ohashi P S, Hengartner H
Institute of Experimental Immunology, University of Zürich, Switzerland.
Science. 1995 Jun 2;268(5215):1343-7. doi: 10.1126/science.7761853.
Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.
只有造血来源的所谓“专业”抗原呈递细胞（APC）被认为能够诱导T淋巴细胞反应。然而，用病毒蛋白转染的成纤维细胞在体内直接诱导抗病毒细胞毒性T淋巴细胞反应，而无需宿主APC参与。成纤维细胞仅在淋巴器官环境中诱导T细胞。因此，抗原定位影响自身与非自身的区分以及基于细胞的疫苗策略。
