Kratz A, Campos-Neto A, Hanson M S, Ruddle N H
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520-8034, USA.
J Exp Med. 1996 Apr 1;183(4):1461-72. doi: 10.1084/jem.183.4.1461.
In presenting a unifying concept for chronic inflammation and lymphoid organogenesis, we suggest that lymphotoxin's (LT, LT-alpha, TNF-beta) crucial role in these processes is pivotal and similar. Chronic inflammatory lesions that developed in the kidney and pancreas at the sites of transgene expression in rat insulin promoter-LT (RIP-LT) mice resembled lymph nodes with regard to cellular composition (T cells, B cells, plasma cells, and antigen-presenting cells), delineated T and B cell areas, primary and secondary follicles, characteristic morphologic and antigenic (ICAM-1, VCAM-1, MAdCAM-1, and PNAd) features of high endothelial venules, and ability to respond to antigen and undergo Ig class switching when obtained from mice immunized with SRBC. The vascular changes, with the exception of PNAd, appear to be the direct consequence of transgene derived LT expression, as they were also observed in RIP-LT mice lacking mature T and B cells. These data show that LT-induced chronic inflammation has the characteristics of organized lymphoid tissue.
在提出一个关于慢性炎症和淋巴器官发生的统一概念时，我们认为淋巴毒素（LT、LT-α、TNF-β）在这些过程中的关键作用是至关重要且相似的。在大鼠胰岛素启动子-LT（RIP-LT）小鼠的转基因表达位点，肾脏和胰腺中出现的慢性炎症病变在细胞组成（T细胞、B细胞、浆细胞和抗原呈递细胞）方面类似于淋巴结，具有划定的T细胞和B细胞区域、初级和次级滤泡、高内皮静脉的特征性形态学和抗原性（ICAM-1、VCAM-1、MAdCAM-1和PNAd）特征，以及从用SRBC免疫的小鼠获取时对抗原作出反应并进行Ig类别转换的能力。除PNAd外，血管变化似乎是转基因衍生的LT表达的直接后果，因为在缺乏成熟T细胞和B细胞的RIP-LT小鼠中也观察到了这些变化。这些数据表明，LT诱导的慢性炎症具有有组织的淋巴组织的特征。
