Gbakima A A, Sahr F
Department of Biological Sciences, Njala University College, University of Sierra Leone.
Public Health. 1996 May;110(3):169-74. doi: 10.1016/s0033-3506(96)80071-0.
In a cross-sectional epidemiological and clinical study of human filariasis, 630 individuals were examined for Onchocerca volvulus, Wuchereria bancrofti and Mansonella perstans infections in five communities in the Kaiyamba Chiefdom, Moyamba District, Sierra Leone. The overall prevalence of O. volvulus infection in males 144(39.1%) and females 94(35.9%) was not significantly different and the sex prevalence rate between communities was also not significant (G = 3, d.f. = 4, P > 0.05). Prevalence of O. volvulus was significantly lower (G = 42.331, d.f. = 5, P < 0.001) in the 5-9 age group (13.3%) compared to the 40-49 age group (61.9%). Sixty-four (10.2%) and 38(6.0%) of individuals examined were positive for W. bancrofti and M. perstans infections respectively and prevalence of both infections in the five communities was not significant. Mixed infections with the all three filaria parasites were recorded in 10(3.2%) of the individuals. One hundred and sixty-four (71.3%) clinical cases due to W. bancrofti were inflammatory in nature; 36.5% were chronic, of which, 26.6% were hydroceles and 9.4% involved elephantiasis of both the scrotum and the lower legs. All 19(3.0%) of M. perstans-related clinical cases were inflammatory. Ninety-three(63.3%) of O. volvulus positive individuals that presented symptoms were inflammatory in nature, 14(9.5%) had ocular symptoms and 57(38.8%) had subcutaneous nodules. These data indicate that infections due to O. volvulus, W. bancrofti and M. perstans may be of public health importance in Sierra Leone.
在一项关于人类丝虫病的横断面流行病学和临床研究中，对塞拉利昂莫扬巴区凯扬巴酋长国五个社区的630人进行了盘尾丝虫、班氏吴策线虫和常现曼森线虫感染情况检查。盘尾丝虫感染在男性中的总体患病率为144例（39.1%），在女性中的总体患病率为94例（35.9%），两者无显著差异，且各社区之间的性别患病率也无显著差异（G = 3，自由度 = 4，P > 0.05）。与40 - 49岁年龄组（61.9%）相比，5 - 9岁年龄组的盘尾丝虫患病率显著较低（G = 42.331，自由度 = 5，P < 0.001）（13.3%）。接受检查的个体中，分别有64例（10.2%）和38例（6.0%）班氏吴策线虫和常现曼森线虫感染呈阳性，且这两种感染在五个社区中的患病率均无显著差异。在10例（3.2%）个体中记录到三种丝虫寄生虫的混合感染。164例（71.3%）由班氏吴策线虫引起的临床病例本质上属于炎症性；36.5%为慢性病例，其中26.6%为鞘膜积液，9.4%涉及阴囊和小腿的象皮肿。所有19例（3.0%）与常现曼森线虫相关的临床病例均为炎症性。出现症状的盘尾丝虫阳性个体中，93例（63.3%）本质上属于炎症性，14例（9.5%）有眼部症状，57例（38.8%）有皮下结节。这些数据表明，盘尾丝虫、班氏吴策线虫和常现曼森线虫感染在塞拉利昂可能具有公共卫生重要性。
