Vesterskiöld L, Schnell P O, Jacobsson H
Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden.
Scand J Rheumatol. 1996;25(3):159-63. doi: 10.3109/03009749609080007.
99Tcm-labelled polyclonal human immunoglobulin 99Tcm-HIG scintigraphy has been suggested as a technique to detect joint inflammation in arthritic disorders. Scintigraphy was performed in fifteen patients with active polyarthritis. All joints except the hips were scored clinically for swelling and pain by a rheumatologist and scintigraphic images were obtained at 30 minutes and four hours after injection of 350MBq 99Tcm-HIG. The images were assessed by a nuclear medicine physician according to a four grade scale. The images were easy to assess. There was a highly significant correlation between swelling and scan score, but no correlation between pain and scan score. The mechanism for the accumulation of activity to inflamed synovial tissue remains unclear. The mean values of the scan score however increased significantly between 30 minutes and 4 hours, indicating an active binding mechanism. The method has a potential as an objective tool in monitoring rheumatic diseases.
99锝标记的多克隆人免疫球蛋白（99锝-HIG）闪烁扫描术已被提议作为一种检测关节炎性疾病关节炎症的技术。对15例活动性多关节炎患者进行了闪烁扫描。除髋关节外，所有关节均由风湿病学家进行临床肿胀和疼痛评分，并在注射350MBq 99锝-HIG后30分钟和4小时获取闪烁扫描图像。核医学医师根据四级评分标准对图像进行评估。图像易于评估。肿胀与扫描评分之间存在高度显著相关性，但疼痛与扫描评分之间无相关性。活性物质在炎症滑膜组织中积聚的机制尚不清楚。然而，扫描评分的平均值在30分钟至4小时之间显著增加，表明存在一种活性结合机制。该方法有潜力作为监测风湿性疾病的客观工具。
