Maiuri F, Iaconetta G, Benvenuti D, Lamaida E, De Caro M L
Institute of Neurosurgery, School of Medicine, University of Naples "Federico II," Italy.
Surg Neurol. 1995 Dec;44(6):556-61. doi: 10.1016/0090-3019(95)00182-4.
A case of meningeal melanocytoma of the left sphenoid wing is reported and the other nine cases in the literature are reviewed. Meningeal melanocytoma is a benign melanotic tumor that derives from the melanocytes of the leptomeninges and may occur anywhere in the cranial and spinal meninges. Electron microscopy well demonstrates melanin and melanosomes within the tumor cells. The immunohistochemical pattern of this tumor includes strong positivity for S-100 protein, vimentin, and antimelanoma antibody and negativity for epithelial membrane antigen, neuron-specific enolase, cytokeratin, and glial fibrillary acidic protein. Complete surgical removal is the treatment of choice, whereas radiotherapy is usually unnecessary. In spite of benign biologic behavior of meningeal melanocytoma, the prognosis remains uncertain, because of the possible local recurrences.
报告了1例左蝶骨嵴脑膜黑素细胞瘤，并复习了文献中的其他9例病例。脑膜黑素细胞瘤是一种良性黑素性肿瘤，起源于软脑膜的黑素细胞，可发生于颅和脊髓脑膜的任何部位。电子显微镜能很好地显示肿瘤细胞内的黑色素和黑素小体。该肿瘤的免疫组化模式包括S-100蛋白、波形蛋白和抗黑素瘤抗体呈强阳性，而上皮膜抗原、神经元特异性烯醇化酶、细胞角蛋白和胶质纤维酸性蛋白呈阴性。完整手术切除是首选治疗方法，而放疗通常不必要。尽管脑膜黑素细胞瘤具有良性生物学行为，但由于可能发生局部复发，其预后仍不确定。
