Dusenbery D, Carr B I
Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania 15213-2582, USA.
Acta Cytol. 1996 May-Jun;40(3):443-9. doi: 10.1159/000333896.
To describe the fine needle aspiration (FNA) findings in metastatic hepatocellular carcinoma (HCC).
The cytologic findings in 15 cases of extrahepatic metastatic HCC diagnosed by FNA biopsy were reviewed.
The anatomic sites of the FNAs were: musculoskeletal (four biopsies from 3 patients), adrenal (4 patients), regional lymph nodes (4 patients), pancreas (2 patients) and pelvic region (1 patient). The 15 aspirates came from 14 patients, 11 of whom had a biopsy-proven primary HCC. In two of the remaining patients, the FNA diagnosis of HCC in the metastatic site was the initial diagnosis. In one of these patients the diagnosis was strongly suspected on clinical grounds, but in the other case it was unsuspected. In the remaining patient the liver mass and massive retroperitoneal adenopathy were biopsied concurrently. A trabecular pattern was observed in the smears and/or cell block preparations in nine cases. Eleven cases were well to moderately differentiated. Three cases were of large cell pleomorphic type. The remaining case was poorly differentiated.
Familiarity with the FNA cytology of HCC should allow its diagnosis in metastatic sites in most instances, even without a history of primary liver cancer.
描述细针穿刺抽吸（FNA）在转移性肝细胞癌（HCC）中的表现。
回顾了15例经FNA活检诊断为肝外转移性HCC的细胞学表现。
FNA的解剖部位包括：肌肉骨骼（3例患者的4次活检）、肾上腺（4例患者）、区域淋巴结（4例患者）、胰腺（2例患者）和盆腔区域（1例患者）。15份抽吸物来自14例患者，其中11例经活检证实为原发性HCC。其余2例患者中，转移性部位的HCC经FNA诊断为初始诊断。其中1例患者临床上高度怀疑该诊断，但另一例则未被怀疑。其余1例患者同时对肝脏肿块和大量腹膜后腺病进行了活检。9例涂片和/或细胞块标本中观察到小梁状模式。11例为高分化至中分化。3例为大细胞多形型。其余1例为低分化。
熟悉HCC的FNA细胞学表现应能在大多数情况下诊断其在转移部位的情况，即使没有原发性肝癌病史。
