Lukac J, Kusić Z, Kovacević D, Soldić Z, Troskot B
Department of Oncology and Nuclear medicine, University Hospital Sestre milosrdnice, HR-Zagreb, Croatia.
Anticancer Res. 1995 Nov-Dec;15(6B):2805-9.
Neutrophil and monocyte phagocytic functions, i.e % of phagocytic cells, ingestion and intracellular microbe killing were determined in 51 patients with colorectal adenocarcinoma, 43 with localized disease and 8 with distant metastases. Phagocytic functions were determined at the time of diagnosis, following surgery are before each of 6 cycles of fluorouracil chemotherapy. Four of six phagocytic parameters determined were decreased at diagnosis while all 6 decreased following surgery. During chemotherapy, neutrophil phagocytic activity recovered to normal value while all other neutrophil and monocyte functions remained decreased. Even so, neutrophil ingestion and monocyte phagocytic and bactericidal activities increased reaching from time to time values significantly higher than that found before the start of chemotherapy. The results showed significant alterations of neutrophil and monocyte phagocytosis in colorectal adenocarcinoma patients at the time of diagnosis, with further decrease following surgery. Fluorouracil chemotherapy did not exert suppressive effects on these functions; on the contrary, it seemed to support, or at least not to prevent, their partial recovery.
在51例结肠直肠癌患者中测定了中性粒细胞和单核细胞的吞噬功能，即吞噬细胞的百分比、摄取和细胞内微生物杀伤情况，其中43例为局限性疾病患者，8例为远处转移患者。在诊断时、手术后以及氟尿嘧啶化疗的6个周期中的每一个周期之前测定吞噬功能。在诊断时所测定的6项吞噬参数中有4项降低，而手术后所有6项参数均降低。在化疗期间，中性粒细胞吞噬活性恢复到正常值，而所有其他中性粒细胞和单核细胞功能仍降低。即便如此，中性粒细胞摄取以及单核细胞吞噬和杀菌活性不时增加，达到显著高于化疗开始前的值。结果显示，结肠直肠癌患者在诊断时中性粒细胞和单核细胞吞噬作用有显著改变，手术后进一步降低。氟尿嘧啶化疗并未对这些功能产生抑制作用；相反，它似乎支持，或至少不阻止它们的部分恢复。
