生长抑素对蛋白酪氨酸磷酸酶的激活及Raf-1的失活作用。
Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin.
作者信息
Reardon D B, Wood S L, Brautigan D L, Bell G I, Dent P, Sturgill T W
机构信息
Howard Hughes Medical Institute, University of Virginia, Charlottesville, VA 22908, U.S.A.
出版信息
Biochem J. 1996 Mar 1;314 ( Pt 2)(Pt 2):401-4. doi: 10.1042/bj3140401.
Abstract
Human somatostatin receptor 3 ('hsstr3') was transiently expressed in NIH 3T3 cells stably transformed with Ha-Ras (G12V). Somatostatin activated a protein tyrosine phosphatase and inactivated the constitutively active, membrane-associated form of the Raf-1 serine kinase present in these cells in vivo and in vitro.
摘要
人类生长抑素受体3（“hsstr3”）在稳定转染Ha-Ras（G12V）的NIH 3T3细胞中瞬时表达。生长抑素激活一种蛋白酪氨酸磷酸酶，并在体内和体外使这些细胞中存在的组成型活性、膜相关形式的Raf-1丝氨酸激酶失活。
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本文引用的文献
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J Biol Chem. 1996 Feb 9;271(6):3119-23. doi: 10.1074/jbc.271.6.3119.
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