发动蛋白II与反式高尔基体网络结合。
Dynamin II binds to the trans-Golgi network.
作者信息
Maier O, Knoblich M, Westermann P
机构信息
Division of Cell Biology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
出版信息
Biochem Biophys Res Commun. 1996 Jun 14;223(2):229-33. doi: 10.1006/bbrc.1996.0876.
Two dynamin II-specific antibodies were used to detect dynamin II attached to highly purified Golgi membranes of HepG2 cells. Within the Golgi apparatus dynamin II is predominantly localized to the trans-Golgi network, as shown by immunoelectron microscopy. Increased binding of dynamin II to the trans-Golgi network in the presence of GTP-gamma-S and a reduced binding upon stimulation of secretion by phorbolester indicates that dynamin II may have a function in post-Golgi vesicle transport.
使用两种动力蛋白 II 特异性抗体来检测附着在 HepG2 细胞高度纯化的高尔基体膜上的动力蛋白 II。免疫电子显微镜显示，在高尔基体中，动力蛋白 II 主要定位于反式高尔基体网络。在存在 GTP-γ-S 的情况下，动力蛋白 II 与反式高尔基体网络的结合增加，而佛波酯刺激分泌后结合减少，这表明动力蛋白 II 可能在高尔基体后囊泡运输中发挥作用。
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