6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids.

作者信息

Marder M, Viola H, Wasowski C, Wolfman C, Waterman P G, Cassels B K, Medina J G, Paladini A C

机构信息

Instituto de Química y Fisicoquímica Biológicas, Facultad de Farmaciay Bioquímica, Buenos Aires, Argentina.

出版信息

Biochem Biophys Res Commun. 1996 Jun 14;223(2):384-9. doi: 10.1006/bbrc.1996.0903.

6-Bromoflavone, obtained by bromination of flavanone, binds to central benzodiazepine receptors with a Ki=70 nM and has a clear anxiolytic activity in mice, at 0.5 mg/kg i.p. A survey of the structure/affinity relationship for those receptors in a series of natural and synthetic flavonoids is presented.