Department of Pharmacology, Department of Pharmacognosy and Isfahan Pharmaceutical Sciences Research Centre, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Evid Based Complement Alternat Med. 2008 Jun;5(2):181-6. doi: 10.1093/ecam/nem017.
The aim of the present study was to evaluate the anxiolytic effects of hydroalcoholic extract (HE) of Nepeta persica Boiss. (Lamiaceae) on the elevated plus-maze (EPM) model of anxiety. The extract of arial parts of the plant was administered intraperitoneally to male NMRI mice, at various doses, 30 min before behavioural evaluation. The HE extract of N. persica at the dose of 50 mg kg(-1) significantly increased the percentage of time spent and percentage of arm entries in the open arms of the EPM. This dose of plant extract affected neither animal's locomotor activity nor ketamine-induced sleeping time. The 50 mg kg(-1) dose of the plant extract seemed to be the optimal dose in producing the anxiolytic effects, lower or higher doses of the plant produce either sedative or stimulant effects. At 100 mg kg(-1), the plant extract increased the locomotor activity. These results suggested that the extract of N. persica at dose of 50 mg kg(-1) possess anxiolytic effect with less sedative and hypnotic effects than that of diazepam and causes a non-specific stimulation at 100 mg kg(-1).
本研究旨在评估 Nepeta persica Boiss.（唇形科）水醇提取物（HE）对焦虑的高架十字迷宫（EPM）模型的抗焦虑作用。将植物地上部分的提取物以不同剂量经腹腔注射给药，在行为评估前 30 分钟给予 NMRI 雄性小鼠。N. persica 的 HE 提取物在 50mg/kg(-1)剂量下显著增加了 EPM 中开放臂的时间百分比和臂进入百分比。该植物提取物的这一剂量既不影响动物的运动活性，也不影响氯胺酮诱导的睡眠时间。植物提取物的 50mg/kg(-1)剂量似乎是产生抗焦虑作用的最佳剂量，较低或较高剂量的植物提取物产生镇静或刺激作用。在 100mg/kg(-1)时，植物提取物增加了运动活性。这些结果表明，N. persica 的提取物在 50mg/kg(-1)剂量下具有抗焦虑作用，镇静和催眠作用小于地西泮，并在 100mg/kg(-1)时引起非特异性刺激。
