原发性雷诺病的家族聚集性。
Familial aggregation of primary Raynaud's disease.
作者信息
Freedman R R, Mayes M D
机构信息
Wayne State University School of Medicine, Detroit, Michigan, USA.
出版信息
Arthritis Rheum. 1996 Jul;39(7):1189-91. doi: 10.1002/art.1780390717.
OBJECTIVE
To determine the occurrence of familial aggregation of primary Raynaud's disease.
METHODS
Twenty-three patients with primary Raynaud's disease and their first-degree relatives were assessed by questionnaire and, when possible, by physical examination. The same procedures were performed on the patients' spouses and the spouses' first-degree relatives, who served as the control group.
RESULTS
The prevalence of Raynaud's disease was significantly higher in the families of the probands than in the control families when assessed by questionnaire (26.1% versus 5.5%; P < 10(-5)), and by physical examination (11.2% versus 2.8%; P = 0.015).
CONCLUSION
These findings demonstrate that there is significant familial aggregation of primary Raynaud's disease.
目的
确定原发性雷诺病的家族聚集性。
方法
通过问卷调查，并在可能的情况下进行体格检查，对23例原发性雷诺病患者及其一级亲属进行评估。对患者的配偶及其配偶的一级亲属进行同样的程序，作为对照组。
结果
通过问卷调查评估时，先证者家族中雷诺病的患病率显著高于对照家族（26.1%对5.5%；P<10⁻⁵），通过体格检查评估时也是如此（11.2%对2.8%；P = 0.015）。
结论
这些发现表明原发性雷诺病存在显著的家族聚集性。
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