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微创治疗雷诺氏综合征的疗效分析。

Efficacy analysis of minimally invasive surgery for Raynaud's syndrome.

机构信息

Hand Microsurgery, Binzhou Medical University Hospital, Binzhou, 256600, China.

The First Clinical School of Binzhou Medical University, Binzhou, 256600, China.

出版信息

BMC Surg. 2023 Oct 14;23(1):313. doi: 10.1186/s12893-023-02225-x.

Abstract

BACKGROUND

Raynaud's syndrome (RS), also referred to as Raynaud's phenomenon, is a vasospastic disorder causing episodic color changes in extremities upon exposure to cold or stress. These manifestations, either primary Raynaud's phenomenon (PRP) or associated with connective tissue diseases like systemic sclerosis (SSc) as secondary Raynaud's phenomenon (SRP), affect the quality of life. Current treatments range from calcium channel blockers to innovative surgical interventions, with evolving efficacy and safety profiles.

METHODS

In this retrospective study, patients diagnosed with RS were selected based on complete medical records, ensuring homogeneity between groups. Surgeries involved microscopic excision of sympathetic nerve fibers and stripping of the digital artery's adventitia. Postoperative care included antibiotics, analgesia, oral nifedipine, and heat therapies. Evaluation metrics such as the VAS pain score and RCS score were collected bi-weekly. Data analysis was conducted using SPSS 26.0, with significance set at p < 0.05.

RESULTS

In total, 15 patients formed the experimental group, with five presenting fingertip soft tissue necrosis and ten showing RS symptoms. Comparative analysis of demographic data between experimental and control groups, both containing 15 participants, demonstrated no significant age and gender difference. However, the "Mean Duration of RP attack" in the experimental group was notably shorter (9.47 min ± 0.31) than the control group (19.33 min ± 1.79). The RS Severity Score also indicated milder severity for the experimental cohort (score: 8.55) compared to the control (score: 11.23). Postoperative assessments at 2, 4, and 6 weeks revealed improved VAS pain scores, RCS scores, and other measures for the experimental group, showing significant differences (p < 0.05). One distinctive case showcased a variation in the common digital nerve and artery course in an RS patient.

CONCLUSION

Our retrospective analysis on RS patients indicates that microsurgical techniques are safe and effective in the short term. As surgical practices lean towards minimally invasive methods, our data supports this shift. However, extensive, prospective studies are essential for conclusive insights.

摘要

背景

雷诺氏综合征(RS),又称雷诺现象,是一种血管痉挛性疾病,导致四肢在暴露于寒冷或压力时出现间歇性颜色变化。这些表现,无论是原发性雷诺现象(PRP)还是与系统性硬化症(SSc)等结缔组织疾病相关的继发性雷诺现象(SRP),都会影响生活质量。目前的治疗方法从钙通道阻滞剂到创新的手术干预,疗效和安全性不断发展。

方法

在这项回顾性研究中,根据完整的病历选择了诊断为 RS 的患者,确保组间的同质性。手术包括交感神经纤维的显微镜切除和指动脉的外膜剥离。术后护理包括抗生素、镇痛药、口服硝苯地平(nifedipine)和热疗。每两周收集一次 VAS 疼痛评分和 RCS 评分等评估指标。使用 SPSS 26.0 进行数据分析,显著性水平设置为 p<0.05。

结果

共有 15 名患者组成实验组,其中 5 名出现指尖软组织坏死,10 名出现 RS 症状。实验组和对照组(每组 15 名患者)的人口统计学数据比较分析显示,年龄和性别无显著差异。然而,实验组的“RP 发作平均持续时间”明显更短(9.47 分钟±0.31),而对照组为(19.33 分钟±1.79)。RS 严重程度评分也表明实验组的严重程度较轻(评分:8.55),而对照组(评分:11.23)则更严重。术后 2、4 和 6 周的评估显示,实验组的 VAS 疼痛评分、RCS 评分和其他指标均有所改善,差异具有统计学意义(p<0.05)。一个独特的病例展示了 RS 患者常见的指总神经和动脉走行的变异。

结论

我们对 RS 患者的回顾性分析表明,显微外科技术在短期内是安全有效的。随着手术实践倾向于微创方法,我们的数据支持这种转变。然而,需要进行广泛的前瞻性研究以获得明确的结论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a61/10576400/fc860df56e45/12893_2023_2225_Fig1_HTML.jpg

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