Schon F, Drayson M, Thompson R A
Department of Neurology, Atkinson Morley's Hospital, Copse Hill, Wimbledon, London SW20 0NE UK.
Age Ageing. 1996 Jan;25(1):56-8. doi: 10.1093/ageing/25.1.56.
Myasthenia gravis is probably commoner than previously suspected, the annual incidence being nearer 9-10/million than earlier figures of 2-4/million. The current study found an annual incidence in Croyden of 9.1 per million (95% confidence limits 5.7-13.8 per million). Of the 22 patients (59%) seen in Croyden with newly diagnosed myasthenia gravis during the past 7 years, 13 were aged over 60. In a separate study of the age distribution of positive acetylcholine receptor antibody assays, 51% were 60 years or above in 1991, and 64% in 1994. The peak age in both sexes was 70-80, and numbers were greatest in men aged 60-80.
重症肌无力可能比之前认为的更为常见,其年发病率接近每百万人口9 - 10例,而非之前的每百万人口2 - 4例。当前研究发现,克罗伊登地区的年发病率为每百万人口9.1例(95%置信区间为每百万人口5.7 - 13.8例)。在过去7年里,克罗伊登地区新诊断出的22例重症肌无力患者中(占59%),有13例年龄超过60岁。在另一项关于乙酰胆碱受体抗体检测阳性患者年龄分布的研究中,1991年60岁及以上患者占51%,1994年占64%。男女的发病高峰年龄均为70 - 80岁,60 - 80岁男性患者数量最多。