Buntinx F, Kester A, Bergers J, Knottnerus J A
Department of General Practice, University of Limburg, PO Box 616, 6200 MD Maastricht, The Netherlands.
Age Ageing. 1996 May;25(3):231-3. doi: 10.1093/ageing/25.3.231.
We used a retrospective cohort study design to test the hypothesis of a relation between old-age depression and subsequent dementia. The study sample comprised 19103 patients aged 50 or more and born after 1910, included in a family-practice-based registration network. We estimated odds ratio (OR) and 95% confidence interval (95% CI) for a diagnosis of dementia in patients with or without previous late-onset depression and survival analysis, including hazard ratios resulting from Cox regression analysis. The OR for a diagnosis of dementia subsequent or not to late-onset depression was found at survival analysis: p = 0.26 (log rank test). Hazard ratio for patients with and without previous old age depression and subsequent dementia in patients aged 50 or more and born after 1910. This supports the hypothesis of old-age depression being a predictor, and possibly a causal factor, of subsequent dementia.
我们采用回顾性队列研究设计来检验老年抑郁症与随后发生痴呆症之间关系的假设。研究样本包括19103名年龄在50岁及以上且出生于1910年以后的患者，这些患者被纳入了一个基于家庭医疗的登记网络。我们估计了有或没有既往晚发性抑郁症患者患痴呆症诊断的比值比（OR）和95%置信区间（95%CI），并进行了生存分析，包括Cox回归分析得出的风险比。在生存分析中发现既往有或无晚发性抑郁症患者随后患痴呆症诊断的OR：p = 0.26（对数秩检验）。1910年以后出生的50岁及以上有或无既往老年抑郁症患者随后患痴呆症的风险比。这支持了老年抑郁症是随后发生痴呆症的一个预测因素，甚至可能是一个因果因素的假设。
