Bas S, Cunningham T, Kvien T K, Glennås A, Melby K, Vischer T L
Division of Rheumatology, University Hospital, Geneva, Switzerland.
Br J Rheumatol. 1996 Jun;35(6):548-52. doi: 10.1093/rheumatology/35.6.548.
Since the presence of Chlamydia has been shown in synovial fluid (SF) from some patients with Chlamydia reactive arthritis, we investigated whether anti-Chlamydia antibodies present in the joint are derived from the circulation or are locally produced. We compared titres of IgG, IgM and IgA antibodies against Chlamydia, and against a control antigen (tetanus toxoid), by an enzyme-linked immunosorbent assay (ELISA), in paired samples of serum and SF from Chlamydia trachomatis sexually acquired reactive arthritis (CT-SARA) patients and from patients with other forms of arthritis. The ratio of serum/SF IgA anti-Chlamydia antibodies was significantly decreased in CT-SARA patients. It is concluded that, in our experimental conditions, we found evidence for intra-articular production of IgA anti-Chlamydia antibodies.
由于在一些衣原体反应性关节炎患者的滑液（SF）中已发现衣原体存在，我们研究了关节中存在的抗衣原体抗体是源自循环系统还是在局部产生。我们通过酶联免疫吸附测定（ELISA），比较了沙眼衣原体性获得性反应性关节炎（CT-SARA）患者以及其他形式关节炎患者的血清和滑液配对样本中，针对衣原体以及对照抗原（破伤风类毒素）的IgG、IgM和IgA抗体滴度。CT-SARA患者血清/滑液IgA抗衣原体抗体的比率显著降低。得出的结论是，在我们的实验条件下，我们发现了关节内产生IgA抗衣原体抗体的证据。
