Narváez J, Rodriguez-Moreno J, Moragues C, Campoy E, Clavaguera T, Roig-Escofet D
Department of Rheumatology, Hospital Príncipes de España, Ciudad Sanitaria, Barcelona, Spain.
Br J Rheumatol. 1996 Jun;35(6):598-600. doi: 10.1093/rheumatology/35.6.598.
We report the development of tertiary hyperparathyrodism in a patient with a sporadic form of adult-onset hypophosphataemic osteomalacia who had been treated with vitamin D or calcitriol and large doses of phosphate. This observation suggests that even with concomitant vitamin D or calcitriol therapy, long-term oral phosphate supplementation may lead to the development of hypercalcaemic hyperparathyrodism. Caution is recommended when relatively large doses of phosphate are used to treat hypophosphataemic osteomalacia of diverse causes.
我们报告了一名散发型成人起病的低磷性骨软化症患者发生三发性甲状旁腺功能亢进症的情况，该患者曾接受维生素D或骨化三醇以及大剂量磷酸盐治疗。这一观察结果表明，即使同时进行维生素D或骨化三醇治疗，长期口服补充磷酸盐也可能导致高钙血症性甲状旁腺功能亢进症的发生。当使用相对大剂量的磷酸盐治疗各种原因引起的低磷性骨软化症时，建议谨慎使用。
