Paus T, Tomaiuolo F, Otaky N, MacDonald D, Petrides M, Atlas J, Morris R, Evans A C
Montreal Neurological Institute, McGill University, Canada.
Cereb Cortex. 1996 Mar-Apr;6(2):207-14. doi: 10.1093/cercor/6.2.207.
Recent advances in functional neuroimaging of the human cerebral cortex revived interest in the study of the cortical morphology at both macro- and microscopic levels. By means of high-resolution magnetic resonance imaging (MRI), in vivo images of the human brain can be acquired and used to aid localization of the functional maps. The goal of the present study was to determine variability in the occurrence and location of the cingulate sulcus (CS) and the paracingulate sulcus (PCS). Brain MRIs of 247 healthy young volunteers were obtained and transformed into a standardized stereotaxic space (Talairach and Tournoux, 1988). The CS and PCS were marked in 494 hemispheres using software capable of real-time movement through a 3-D volume. The markers were used to generate a probabilistic map of the CS and PCS. The individual MRI images were also evaluated for the presence and location of the following morphological features: the continuity of the CS, the presence of vertically oriented branches of the CS, the presence of the PCS, and the presence of the intralimbic sulcus. The results revealed considerable variability in the location of some of the above morphological features and a striking hemispheric asymmetry in the prominence of the PCS. The results of four previous blood-flow activation studies of speech control were used to illustrate the relevance of our morphological findings for functional neuroimaging of the human anterior cingulate cortex.
人类大脑皮质功能神经影像学的最新进展，重新唤起了人们对宏观和微观层面皮质形态学研究的兴趣。借助高分辨率磁共振成像（MRI），可以获取人脑的活体图像，并用于辅助功能图谱的定位。本研究的目的是确定扣带沟（CS）和旁扣带沟（PCS）出现的部位及位置的变异性。获取了247名健康年轻志愿者的脑部MRI图像，并将其转换为标准化的立体定向空间（Talairach和Tournoux，1988）。使用能够在三维容积中实时移动的软件，在494个半球上标记了CS和PCS。这些标记用于生成CS和PCS的概率图谱。还对个体MRI图像评估了以下形态学特征的存在情况和位置：CS的连续性、CS垂直分支的存在情况、PCS的存在情况以及边缘内沟的存在情况。结果显示，上述一些形态学特征的位置存在相当大的变异性，并且PCS的突出程度存在显著的半球不对称性。之前四项关于言语控制的血流激活研究结果，被用于说明我们的形态学发现对于人类前扣带皮质功能神经影像学的相关性。
