Baker S C, Frith C D, Frackowiak R S, Dolan R J
Wellcome Department of Cognitive Neurology, Institute of Neurology, WC1N 3BG and MRC Cyclotron Unit, Hammersmith Hospital, London W12 0HS, UK.
Cereb Cortex. 1996 Jul-Aug;6(4):612-9. doi: 10.1093/cercor/6.4.612.
Neural activity during the delay period of spatial delayed response (DR) and delayed matching (DM) tasks was investigated by positron emission tomography. A distributed cortical system was activated in each condition. The bilateral dorsolateral prefrontal cortex (DLPFC) was activated in the delay period of both tasks; activation was of higher significance on the right in the DR task and the left in the DM task, and extended to the anterolateral prefrontal cortex in the DM condition. Active representation of spatial location in the DR task was associated with co-activation of the medial and lateral parietal cortex and the extrastriate visual cortex. Active representation of shape in the DM task was associated with co-activation of medial and lateral parietal cortex and the inferior temporal cortex. Response-related activity was observed in both tasks. Activation of anterior cingulate, inferior frontal, lateral promotor and rostral inferior parietal cortex was observed in the DR condition, a task characterized by preparation of a movement to a predetermined location. In contrast, preparation to move to an undetermined location in the DM task was associated with activation predominantly in rostral SMA.
采用正电子发射断层扫描技术研究了空间延迟反应（DR）和延迟匹配（DM）任务延迟期的神经活动。在每种情况下均激活了一个分布式皮质系统。在两项任务的延迟期均激活了双侧背外侧前额叶皮质（DLPFC）；在DR任务中右侧激活的显著性更高，而在DM任务中左侧激活的显著性更高，并且在DM情况下激活范围扩展至前额叶前外侧皮质。DR任务中空间位置的主动表征与内侧和外侧顶叶皮质以及纹外视觉皮质的共同激活相关。DM任务中形状的主动表征与内侧和外侧顶叶皮质以及颞下皮质的共同激活相关。在两项任务中均观察到了与反应相关的活动。在DR情况下观察到前扣带回、额下回、外侧运动前区和嘴侧顶下皮质的激活，DR任务的特点是准备向预定位置移动。相比之下，在DM任务中准备向不确定位置移动主要与嘴侧辅助运动区的激活相关。
