Marsden P J, Murdoch A, Taylor R
Centre for Reproductive Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK.
Hum Reprod. 1996 May;11(5):968-74. doi: 10.1093/oxfordjournals.humrep.a019333.
The relationship between the menstrual cycle and insulin sensitivity is unclear. The aim of this study was to investigate insulin sensitivity during the normal menstrual cycle using the physiological insulin target organ adipose tissue. A total of 23 normal healthy volunteers were studied, nine of whom were in the follicular phase, and 14 of whom were age and body mass index-matched and in the luteal phase of the menstrual cycle. Adipocyte insulin receptor binding was measured and adipocyte insulin action was assessed by measuring initial rates of 3-O-methylglucose uptake and by inhibition of lipolysis. The maximum specific insulin receptor binding was significantly higher in subjects studied during the follicular phase of the menstrual cycle compared to subjects studied during the luteal phase (1.81 +/- 0.13 versus 1.36 +/- 0.15% per 10 cm2 cell surface, P < 0.05). Maximum rates of 3-O-methylglucose transport were 1.70 +/- 0.22 versus 1.75 +/- 0.22 pmol/10 cm2/5 s in the follicular and luteal phase respectively and were not significantly different between the two groups. The maximum percentage lipolysis inhibition observed was 42. 5 +/- 7.5% in the follicular phase and 39.9 +/- 7.4% in the luteal phase (not significant). This study demonstrated that there is a reduction in insulin receptor binding in the luteal phase of the normal ovulatory menstrual cycle. The post-receptor action of insulin is not affected between the two phases of the menstrual cycle.
月经周期与胰岛素敏感性之间的关系尚不清楚。本研究的目的是利用生理性胰岛素靶器官脂肪组织，调查正常月经周期中的胰岛素敏感性。共对23名正常健康志愿者进行了研究，其中9人处于卵泡期，另外14人年龄和体重指数相匹配，处于月经周期的黄体期。测量脂肪细胞胰岛素受体结合情况，并通过测量3 - O - 甲基葡萄糖摄取的初始速率以及抑制脂肪分解来评估脂肪细胞胰岛素作用。与在黄体期研究的受试者相比，在月经周期卵泡期研究的受试者的最大特异性胰岛素受体结合显著更高（每10 cm²细胞表面分别为1.81±0.13与1.36±0.15%，P < 0.05）。卵泡期和黄体期3 - O - 甲基葡萄糖转运的最大速率分别为1.70±0.22与1.75±0.22 pmol/10 cm²/5 s，两组之间无显著差异。观察到的最大脂肪分解抑制百分比在卵泡期为42.5±7.5%，在黄体期为39.9±7.4%（无显著差异）。本研究表明，在正常排卵月经周期的黄体期，胰岛素受体结合减少。月经周期的两个阶段之间，胰岛素的受体后作用不受影响。
