Wyskida Katarzyna, Franik Grzegorz, Wikarek Tomasz, Owczarek Aleksander, Delroba Alham, Chudek Jerzy, Sikora Jerzy, Olszanecka-Glinianowicz Magdalena
Health Promotion and Obesity Management UnitDepartment of Pathophysiology, Medical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland.
Department of Gynecological EndocrinologyMedical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland.
Endocr Connect. 2017 Nov;6(8):892-900. doi: 10.1530/EC-17-0186. Epub 2017 Oct 27.
The aim of this study was to assess the plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 levels in relation to hormonal changes during the menstrual cycle in young, healthy, normal-weight women.
The study involved 52 young, healthy, normal-weight women. Anthropometric parameters, body composition and levels of plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 in addition to serum FSH, LH, estradiol, progesterone, 17-OH progesterone, androgens, SHBG and insulin concentrations were measured during a morning in fasting state three times: between days 2-4, days 12-14 and days 24-26 of the menstrual cycle.
Plasma adiponectin, omentin-1, resistin and visfatin/NAMPT, apelin, TNF-α, IL-6 and RBP4 concentrations were stable during the menstrual cycle, while leptin and vaspin levels were significantly higher in both the midcycle and the luteal phases than those in the follicular phase. Multivariate regression analyses revealed that changes in leptin and vaspin levels between the follicular and the luteal phase are strongly related to changes in total testosterone levels.
Our results revealed stable levels of adipokines during the phases of the physiological menstrual cycle, except for leptin and vaspin, which showed increased levels in both the midcycle and the luteal phases. This effect was significantly associated with changes in the secretion of testosterone, 17-OH progesterone and insulin in the luteal phase.
本研究旨在评估年轻、健康、体重正常的女性在月经周期中，血浆瘦素、脂联素、抵抗素、内脂素/烟酰胺磷酸核糖转移酶（visfatin/NAMPT）、网膜素-1、内脏脂肪素（vaspin）、Apelin、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和视黄醇结合蛋白4（RBP4）水平与激素变化的关系。
该研究纳入了52名年轻、健康、体重正常的女性。除了血清促卵泡生成素（FSH）、促黄体生成素（LH）、雌二醇、孕酮、17-羟孕酮、雄激素、性激素结合球蛋白（SHBG）和胰岛素浓度外，还在月经周期的第2 - 4天、第12 - 14天和第24 - 26天的空腹状态下的早晨，测量了人体测量参数、身体成分以及血浆瘦素、脂联素、抵抗素、内脂素/烟酰胺磷酸核糖转移酶、网膜素-1、内脏脂肪素、Apelin、TNF-α、IL-6和RBP4的水平。
血浆脂联素、网膜素-1、抵抗素和内脂素/烟酰胺磷酸核糖转移酶、Apelin、TNF-α、IL-6和RBP4浓度在月经周期中保持稳定，而瘦素和内脏脂肪素水平在月经周期的中期和黄体期均显著高于卵泡期。多变量回归分析显示，卵泡期和黄体期之间瘦素和内脏脂肪素水平的变化与总睾酮水平的变化密切相关。
我们的研究结果显示，在生理月经周期各阶段，除瘦素和内脏脂肪素外，脂肪因子水平保持稳定，瘦素和内脏脂肪素在月经周期中期和黄体期水平升高。这种效应与黄体期睾酮、17-羟孕酮和胰岛素分泌的变化显著相关。
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