Llahi-Camp J M, Rai R, Ison C, Regan L, Taylor-Robinson D
Department of Obstetrics and Gynaecology, Imperial College School of Medicine at St Mary's, Paddington, London W2, UK.
Hum Reprod. 1996 Jul;11(7):1575-8. doi: 10.1093/oxfordjournals.humrep.a019440.
The aim of this study was to determine whether bacterial vaginosis (BV) is associated with a history of recurrent pregnancy loss. A total of 500 consecutive patients attending the Recurrent Miscarriage Clinic were screened for the presence of BV. In women who had had at least one late miscarriage BV was found twice as commonly (27/130; 21%) as in women who had had only early losses (31/370; 8%) (P < 0.001). The difference was even larger (26 versus 8%) if women who had had term pregnancies were excluded. Moreover, BV was found three times more commonly in Afro-Caribbean women [17 (29%) of 58] than in Caucasian women [36 (9%) of 379] and, in both groups of women, BV was diagnosed at least twice as frequently in those with a history of at least one late miscarriage than in those who had experienced first trimester pregnancy losses only (P < 0. 001). The condition occurred twice as often among smokers than non-smokers and, in both groups, it was at least twice as common in women with a history of at least one late miscarriage as in those who had had early pregnancy losses only (P < 0.001). However, the relationship between BV and smoking was independent of ethnic origin. Women who douched with chloroxylenol were mostly Afro-Caribbean and had BV more than twice as often as women who did not douche.
本研究的目的是确定细菌性阴道病（BV）是否与复发性流产史相关。对连续500名前往复发性流产诊所就诊的患者进行了BV筛查。在至少有一次晚期流产的女性中，BV的检出率（27/130；21%）是仅有早期流产的女性（31/370；8%）的两倍（P<0.001）。如果排除有足月妊娠的女性，差异会更大（26%对8%）。此外，非裔加勒比女性中BV的检出率[58例中有17例（29%）]是白种女性[379例中有36例（9%）]的三倍，并且在两组女性中，至少有一次晚期流产史的女性BV诊断率至少是仅经历过孕早期流产的女性的两倍（P<0.001）。吸烟者中BV的发生率是非吸烟者的两倍，并且在两组中，至少有一次晚期流产史的女性BV发生率至少是仅有早期妊娠流产史女性的两倍（P<0.001）。然而，BV与吸烟之间的关系与种族无关。用对氯间二甲苯酚冲洗阴道的女性大多是非裔加勒比人，其BV发生率是未冲洗女性的两倍多。
