SWXJ重组自交系群体中简单序列长度多态性（SSLP）标记的菌株分布模式：第7号染色体至X染色体。

Strain distribution pattern for SSLP markers in the SWXJ recombinant inbred strain set: chromosomes 7 to X.

作者信息

Shultz K L, Svenson K L, Cheah Y, Paigen B, Beamer W G

机构信息

Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.

出版信息

Mamm Genome. 1996 Jul;7(7):526-32. doi: 10.1007/s003359900156.

DOI:10.1007/s003359900156

PMID:8672132

Abstract

The SWXJ recombinant inbred (RI) set was developed for genetic analysis of heritable ovarian tumors. In this report we present data for 223 simple sequence length polymorphisms spanning Chromosomes (Chrs) 7-X to complete the genetic marking of this RI set. The strain distribution patterns (SDP) for these loci were combined with data from 19 other polymorphic genes, resulting in densely marked maps for Chrs 7-X. Combined with the 165 loci for Chr 1-6 reported previously (Svenson et al., Mamm. Genome 6, 867, 1995), the SWXJ RI set represents a powerful tool for mapping genes in neoplastic as well as other heritable disorders.

摘要

开发SWXJ重组近交（RI）系用于遗传性卵巢肿瘤的遗传分析。在本报告中，我们展示了跨越染色体（Chr）7 - X的223个简单序列长度多态性的数据，以完成该RI系的遗传标记。这些位点的菌株分布模式（SDP）与来自其他19个多态性基因的数据相结合，从而得到了Chr 7 - X的密集标记图谱。结合先前报道的Chr 1 - 6的165个位点（Svenson等人，《哺乳动物基因组》6, 867, 1995），SWXJ RI系是在肿瘤及其他遗传性疾病中进行基因定位的有力工具。