维持治疗期间脑锂水平的变异性：一项磁共振波谱研究。

Variability of brain lithium levels during maintenance treatment: a magnetic resonance spectroscopy study.

作者信息

Sachs G S, Renshaw P F, Lafer B, Stoll A L, Guimarães A R, Rosenbaum J F, Gonzalez R G

机构信息

Harvard Bipolar Research Program, Consolidated Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

出版信息

Biol Psychiatry. 1995 Oct 1;38(7):422-8. doi: 10.1016/0006-3223(94)00324-v.

DOI:10.1016/0006-3223(94)00324-v

PMID:8672602

Abstract

In vivo magnetic resonance spectroscopy (MRS) was used to determine the relationship between serum and brain lithium levels in bipolar patients (n=25). Over the broad range of serum lithium levels observed, the correlation (r=.68) with brain lithium levels was high. This correlation was much weaker (r=.39) when limited to only those patients with serum lithium levels in the range of 0.6-1.0 mmol/l. This variability may account for failure of lithium prophylaxis in some patients who have serum lithium levels in the therapeutic range.

摘要

采用体内磁共振波谱（MRS）来确定双相情感障碍患者（n = 25）血清锂水平与脑锂水平之间的关系。在所观察到的血清锂水平的广泛范围内，与脑锂水平的相关性（r = 0.68）较高。当仅局限于血清锂水平在0.6 - 1.0 mmol/L范围内的患者时，这种相关性则弱得多（r = 0.39）。这种变异性可能解释了一些血清锂水平处于治疗范围内的患者锂预防治疗失败的原因。