通过心室功能评估甲泼尼龙对缺血心肌的保护作用。
Protective effect of methylprednisolone on ischaemic myocardium assessed by ventricular function.
作者信息
Krause B L, Hassan M A, McMilan A B, Brown A H
出版信息
Thorax. 1977 Apr;32(2):185-93. doi: 10.1136/thx.32.2.185.
Intracardiac surgical procedures are best carried out when the heart is still and bloodless. This condition, however, produces myocardial cellular damage with loss of contractility and compliance unless some protection can be provided. Myocardial contractility and compliance is best studied by isovolumic ventricular function tests, which were used to evaluate the protective effect of methylprednisolone on the isolated cross-perfused canine heart made ischaemic for 2 hours. Control experiments included 2 hours of ischaemia without methylprednisolone, and 2 hours of continuous normothermic cross-perfusion. The methylprednisolone-treated hearts had probably significantly better ventricular function after 2 hours of ischaemia than did hearts without the methylprednisolone, while the cross-perfused hearts were best overall. This work suggests that methylprednisolone may have a protective effect on the ischaemic myocardium of the intact canine heart.
心内手术最好在心脏静止且无血的状态下进行。然而，这种状态会导致心肌细胞损伤，使收缩性和顺应性丧失，除非能提供某种保护措施。心肌收缩性和顺应性最好通过等容心室功能测试来研究，该测试用于评估甲基强的松龙对离体交叉灌注的犬心脏的保护作用，该犬心脏缺血2小时。对照实验包括在无甲基强的松龙的情况下缺血2小时，以及2小时的持续常温交叉灌注。缺血2小时后，接受甲基强的松龙治疗的心脏的心室功能可能明显优于未接受甲基强的松龙治疗的心脏，而交叉灌注的心脏总体表现最佳。这项研究表明，甲基强的松龙可能对完整犬心脏的缺血心肌具有保护作用。
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