腺苷酸能量电荷与ATP/ADP比值协同变化的建模：在无脊椎动物和脊椎动物骨骼肌能量代谢中的应用
Modelization of coordinated changes of adenylate energy charge and ATP/ADP ratio: application to energy metabolism in invertebrate and vertebrate skeletal muscle.
作者信息
Raffin J P, Thébault M T
机构信息
Laboratoire de biotechnologie des micro-organismes hydrothermaux, Collège de France, Concarneau, France.
出版信息
C R Acad Sci III. 1996 Jan;319(1):9-15.
Regulation of the coordinated adenylate energy charge (AEC) and ATP/ADP ratio variations was studied with the aid of computer-made simulations. When the equilibrium state for the adenylate kinase-catalyzed reaction has been assumed, the function describing the coordinated AEC and ATP/ADP ratio variations can be simply derived from the formulas describing these 2 parameters. The model was used to analyze incidence of AMP deamination in the coordinated regulation of cellular energy metabolism.
借助计算机模拟研究了腺苷酸能量电荷（AEC）和ATP/ADP比值变化的协同调节。当假设腺苷酸激酶催化反应处于平衡状态时，描述AEC和ATP/ADP比值协同变化的函数可直接从描述这两个参数的公式推导得出。该模型用于分析AMP脱氨在细胞能量代谢协同调节中的发生率。
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