Schwerdtle R F, Störkel S, Neuhaus C, Brauch H, Weidt E, Brenner W, Hohenfellner R, Huber C, Decker H J
Department of Hematology, Johannes Gutenberg University, Mainz, Germany.
Cancer Res. 1996 Jul 1;56(13):2927-30.
We analyzed 50 sporadic renal cell carcinomas (RCCs) for loss of heterozygosity (LOH) at the chromosomal regions 1p, 2p, 6p, 7q, 10p, 11p, 13q, 14q, 17p, 21q, and 22q. Histologically, the tumors were distinguished into clear cell, chromophilic, and chromophobe carcinomas. Whereas LOH at 14q was identified in 42-64% of all three tumor types, only the chromophobe tumors showed high frequencies of LOH (73-91%) at 1p, 2p, 6p, 10p, 13q, 17p, and 21q. These findings provide substantial evidence that the chromophobe subtype of RCC represents a distinct genetic entity. Thus, specific LOH patterns may define the histogenesis and oncogenesis of chromophobe RCC and may be useful in tumor diagnosis and clinical prognosis.
我们分析了50例散发性肾细胞癌（RCC），以检测1p、2p、6p、7q、10p、11p、13q、14q、17p、21q和22q染色体区域的杂合性缺失（LOH）情况。在组织学上，这些肿瘤被区分为透明细胞癌、嗜酸性细胞癌和嫌色细胞癌。虽然在所有三种肿瘤类型中，14q的LOH发生率为42%-64%，但只有嫌色细胞肿瘤在1p、2p、6p、10p、13q、17p和21q显示出高频率的LOH（73%-91%）。这些发现提供了充分的证据，表明RCC的嫌色细胞亚型代表一种独特的遗传实体。因此，特定的LOH模式可能界定嫌色细胞RCC的组织发生和肿瘤发生，并且可能有助于肿瘤诊断和临床预后判断。
