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[精神分裂症中的快感缺失]

[Anhedonia in schizophrenia].

作者信息

Loas G, Boyer P, Legrand A, Gayant C, Delahousse J

机构信息

Secteur Hospitalo-Universitaire de Psychiatrie, Hôpital Pinel, Amiens.

出版信息

Encephale. 1995 Nov-Dec;21(6):453-7.

PMID:8674470
Abstract

A study on 61 subjects who meet Spitzer's Research Diagnosis Criteria of schizophrenia and on 56 normal subjects has been conducted to explore anhedonia. Anhedonia was evaluated by two rating scales, the Physical Anhedonia Scale (PAS) and a sub-scale of physical pleasure (FCPCS-PP) extracted from the pleasure scale of Fawcett. The reliabilities of the scales were studied in the schizophrenic group by the Cronbach alpha and the Kuder Richardson (KR 20) coefficient and by the correlation between the two scales (concurrent validity). The Cronbach alpha was 0.77 for the FCPCS-PP and the KR 20 was 0.82 for the PAS. The correlation between the two scales was -0.37 (p < 0.01). The schizophrenics were significantly more anhedonic than normals with higher score on the PAS and with a lower score on the FCPCS-PP. Using the Beck Depression Inventory to rate depression in the schizophrenic group and to dichotomize these subjects into depressed schizophrenics and no depressed schizophrenics, we failed to find significantly differences concerning anhedonia scales between these two sub-groups of schizophrenics. There was no difference between in and outpatients concerning the anhedonia scales. Our results suggest that anhedonia would be a possible marker of schizophrenic disease. The distribution of the anhedonia scales in the schizophrenic group is normal or unimodal and it doesn't support the hypothesis of a qualitative sub-group of schizophrenics characterised by severe anhedonia.

摘要

一项针对61名符合斯皮策精神分裂症研究诊断标准的受试者以及56名正常受试者的研究,旨在探讨快感缺失。通过两个评定量表对快感缺失进行评估,即身体快感缺失量表(PAS)以及从福西特快感量表中提取的身体愉悦子量表(FCPCS-PP)。通过克朗巴赫α系数和库德-理查森(KR 20)系数,以及两个量表之间的相关性(同时效度),对精神分裂症组中量表的信度进行了研究。FCPCS-PP的克朗巴赫α系数为0.77,PAS的KR 20系数为0.82。两个量表之间的相关性为-0.37(p<0.01)。精神分裂症患者的快感缺失明显比正常人更严重,PAS得分更高,而FCPCS-PP得分更低。使用贝克抑郁量表对精神分裂症组的抑郁程度进行评分,并将这些受试者分为抑郁型精神分裂症患者和非抑郁型精神分裂症患者,我们未能发现这两个精神分裂症亚组在快感缺失量表方面存在显著差异。门诊患者和住院患者在快感缺失量表方面没有差异。我们的结果表明,快感缺失可能是精神分裂症的一个标志。精神分裂症组中快感缺失量表的分布是正常的或单峰的,不支持存在以严重快感缺失为特征的精神分裂症定性亚组这一假设。

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