Hayes H M, Tarone R E, Cantor K P
Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
Environ Res. 1995 Aug;70(2):119-25. doi: 10.1006/enrs.1995.1056.
In response to criticisms raised regarding a case-control study of canine malignant lymphoma, the results of several ancillary analyses are reported. The case-control study demonstrated a significant association between risk for canine malignant lymphoma and the opportunity for exposure to 2,4-dichlorophenoxyacetic acid herbicides. It is demonstrated that risk estimates do not vary by type of control group (i.e., tumor control or nontumor control group), by method of response (i.e., self-administered or telephone interview), or by geographic area. Questions related to the potential for referral bias, supposed inconsistencies in subject responses regarding frequency of herbicide use, and ambiguities regarding exposure classification are also examined.
针对对一项犬类恶性淋巴瘤病例对照研究提出的批评，报告了几项辅助分析的结果。该病例对照研究表明，犬类恶性淋巴瘤风险与接触2,4-二氯苯氧基乙酸除草剂的机会之间存在显著关联。结果表明，风险估计值不因对照组类型（即肿瘤对照组或非肿瘤对照组）、应答方式（即自行填写或电话访谈）或地理区域而有所不同。还研究了与转诊偏倚可能性、受试者关于除草剂使用频率的应答中可能存在的不一致性以及接触分类的模糊性相关的问题。
