Division of Biostatistics and Epidemiology, Department of Public Health, School of Public Health and Health Sciences, Arnold House, University of Massachusetts, 715 North Pleasant Street, Amherst, MA 01003-9304, USA.
Environ Res. 2012 Jan;112:171-6. doi: 10.1016/j.envres.2011.12.003. Epub 2012 Jan 4.
Epidemiologic studies of companion animals offer an important opportunity to identify risk factors for cancers in animals and humans. Canine malignant lymphoma (CML) has been established as a model for non-Hodgkin's lymphoma (NHL). Previous studies have suggested that exposure to environmental chemicals may relate to development of CML.
We assessed the relation of exposure to flea and tick control products and lawn-care products and risk of CML in a case-control study of dogs presented to a tertiary-care veterinary hospital (2000-2006). Cases were 263 dogs with biopsy-confirmed CML. Controls included 240 dogs with benign tumors and 230 dogs undergoing surgeries unrelated to cancer. Dog owners completed a 10-page questionnaire measuring demographic, environmental, and medical factors.
After adjustment for age, weight, and other factors, use of specific lawn care products was associated with greater risk of CML. Specifically, the use of professionally applied pesticides was associated with a significant 70% higher risk of CML (odds ratio(OR)=1.7; 95% confidence interval (CI)=1.1-2.7). Risk was also higher in those reporting use of self-applied insect growth regulators (OR=2.7; 95% CI=1.1-6.8). The use of flea and tick control products was unrelated to risk of CML.
Results suggest that use of some lawn care chemicals may increase the risk of CML. Additional analyses are needed to evaluate whether specific chemicals in these products may be related to risk of CML, and perhaps to human NHL as well.
伴侣动物的流行病学研究为确定动物和人类癌症的风险因素提供了重要机会。犬恶性淋巴瘤（CML）已被确立为非霍奇金淋巴瘤（NHL）的模型。先前的研究表明，接触环境化学物质可能与 CML 的发生有关。
我们在一家三级兽医医院（2000-2006 年）对就诊的犬进行了病例对照研究，评估了跳蚤和蜱控制产品以及草坪护理产品的暴露与 CML 风险的关系。病例为 263 只经活检证实患有 CML 的犬。对照组包括 240 只患有良性肿瘤的犬和 230 只接受与癌症无关的手术的犬。犬主人完成了一份 10 页的问卷，测量了人口统计学、环境和医疗因素。
在调整了年龄、体重和其他因素后，使用特定的草坪护理产品与 CML 的风险增加相关。具体而言，使用专业应用的杀虫剂与 CML 的风险显著增加 70%相关（比值比（OR）=1.7；95%置信区间（CI）=1.1-2.7）。报告使用自行应用的昆虫生长调节剂的风险也更高（OR=2.7；95% CI=1.1-6.8）。使用跳蚤和蜱控制产品与 CML 的风险无关。
结果表明，使用某些草坪护理化学品可能会增加 CML 的风险。需要进一步分析以评估这些产品中的特定化学物质是否与 CML 的风险有关，也许与人类 NHL 也有关。
